Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 1.00 |
| ▸ | BTK | Q06187 | 7/20 | 1.00 |
| ▸ | JAK3 | P52333 | 5/20 | 1.00 |
| ▸ | ITK | Q08881 | 7/20 | 0.61 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15900235 | 1.00 | EGFR (1.00) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL2229429 | 1.00 | EGFR (1.00) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL17620270 | 0.91 | EGFR (1.00) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL2226808 | 0.91 | EGFR (1.00) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL24486574 | 0.87 | EGFR (0.77) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL13166864 | 0.83 | EGFR (0.82) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL2226811 | 0.80 | EGFR (0.71) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL13165523 | 0.80 | EGFR (0.77) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL20927122 | 0.80 | EGFR (0.66) | EGFRBTKJAK3ITKSYK | |
| SCHEMBL12518406 | 0.79 | JAK1 (0.69) | EGFRBTKJAK3ITKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11351168-B1 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | CELGENE CAR LLC (BM) | 2022-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11351168-B1 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | DCK, CDK2, DTYMK | EGFR 460/4885BTK 261/4885JAK3 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.