Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.56 |
| ▸ | CDC7 | O00311 | 3/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.54 |
| ▸ | PAK4 | O96013 | 3/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | PRKACA | P17612 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 3/20 | 0.54 |
| ▸ | CLK2 | P49760 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | CDK7 | P50613 | 3/20 | 0.54 |
| ▸ | CDK9 | P50750 | 3/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.54 |
| ▸ | STK3 | Q13188 | 3/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.54 |
| ▸ | MELK | Q14680 | 3/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14475789 | 0.86 | SIRT2 (0.45) | PIK3CACDC7ROCK2PRKD3PAK4 | |
| SCHEMBL20439526 | 0.85 | MAPK14 (0.68) | PIK3CACDC7ROCK2PRKD3PAK4 | |
| SCHEMBL14726035 | 0.82 | CYP1A2 (0.63) | LMNACLK4KDM1AMAPK1HSD17B10 | |
| SCHEMBL3180748 | 0.82 | PIK3CA (0.49) | PIK3CACDC7ROCK2PRKD3PAK4 | |
| SCHEMBL14474395 | 0.80 | ADORA3 (0.52) | PIM1LMNACLK4LATS1MAPK1 | |
| SCHEMBL14475137 | 0.80 | PTK2 (0.48) | PIM1LMNAALKMAPK9MAPK10 | |
| SCHEMBL3180481 | 0.79 | PIK3CA (0.52) | PIK3CACDC7ROCK2PRKD3PAK4 | |
| SCHEMBL14727142 | 0.79 | PDE5A (0.58) | LMNACLK4MAPK1HSD17B10KMT2A | |
| SCHEMBL14474866 | 0.79 | MAPT (0.54) | LMNACLK4MAPK1HSD17B10KMT2A | |
| SCHEMBL14475510 | 0.79 | MCL1 (0.51) | CDC7ROCK2PRKD3PAK4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486270-B2 | Receptor tyrosine kinase inhibitors for treatment of protein kinase modulation-responsive disease or disorder | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2025-12-02 | — | — | US | disclosed |
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486270-B2 | Receptor tyrosine kinase inhibitors for treatment of protein kinase modulation-responsive disease or disorder | EPHA1, EPHB2, EPHB1 | PIK3CA 912/4885CDC7 299/4885ROCK2 252/4885 |
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | EPHA1, EPHB2, EPHB1 | PIK3CA 912/4885CDC7 299/4885ROCK2 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.