Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 6/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14688819 | 1.00 | DYRK1A (0.33) | DYRK1AGSK3AGSK3BPIM1JAK2 | |
| SCHEMBL30661625 | 0.85 | PDPK1 (0.35) | DYRK1AJAK2PDPK1CHEK1AURKA | |
| SCHEMBL16340015 | 0.85 | PDPK1 (0.35) | DYRK1AJAK2PDPK1CHEK1AURKA | |
| SCHEMBL17514104 | 0.78 | JAK2 (0.53) | DYRK1AGSK3AGSK3BJAK2PDPK1 | |
| SCHEMBL12481324 | 0.77 | PIM1 (0.33) | DYRK1AGSK3AGSK3BPIM1PIM3 | |
| SCHEMBL13906113 | 0.77 | ADORA2A (0.44) | DYRK1AGSK3AGSK3BPIM1JAK2 | |
| SCHEMBL16525301 | 0.77 | GABRP (0.43) | GSK3AGSK3BPIM1PIM3PIM2 | |
| SCHEMBL16517816 | 0.77 | GABRP (0.47) | DYRK1APDPK1CHEK1AURKAROCK1 | |
| SCHEMBL4145448 | 0.74 | GABRP (0.46) | PIM1CHEK1 | |
| SCHEMBL16608547 | 0.73 | PIM1 (0.44) | DYRK1APIM1CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025235733-A1 | BIS-BICYCLOHETEROARYL MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2025-11-13 | — | — | WO | disclosed |
| WO-2024148247-A2 | AZAINDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |
| EP-4262796-A1 | MACROCYCLES AND THEIR USE | Blossomhill Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022133037-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2022-06-23 | — | — | WO | disclosed |