Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ASPH | Q12797 | 2/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 7/20 | 0.36 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28371872 | 0.77 | KDM4E (0.41) | KDM4EASPHKDM8KDM5APLCG1 | |
| SCHEMBL27830741 | 0.73 | SMN1; SMN2 (0.42) | KDM4EASPHKDM8KDM5APLCG1 | |
| SCHEMBL3465039 | 0.73 | PLCG1 (0.38) | KDM4EASPHKDM8KDM5APLCG1 | |
| SCHEMBL6595252 | 0.73 | KDM5B (0.38) | KDM4EASPHKDM8KDM5APLCG1 | |
| SCHEMBL29740944 | 0.72 | KDM4E (0.40) | KDM4EASPHKDM8KDM5AL3MBTL1 | |
| SCHEMBL7626461 | 0.71 | CYP1A2 (0.48) | KDM4ETDP1ALDH1A1ALOX15TSHR | |
| SCHEMBL29740979 | 0.71 | LRRK2 (0.47) | KDM4EKDM5ALMNATDP1ALDH1A1 | |
| SCHEMBL22890667 | 0.71 | LRRK2 (0.47) | KDM4EKDM5ALMNATDP1ALDH1A1 | |
| SCHEMBL1663588 | 0.69 | KDM4E (0.57) | KDM4EPLCG1KDM4CL3MBTL1KDM4A | |
| SCHEMBL30630522 | 0.69 | PLCG1 (0.37) | KDM4EPLCG1KDM4CRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022155419-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2022-07-21 | — | — | WO | disclosed |