Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.55 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972427 | 1.00 | IMPDH2 (0.55) | IMPDH2IMPDH1CTSLALDH1A1HTT | |
| SCHEMBL19747754 | 0.82 | BCHE (0.59) | IMPDH2IMPDH1CTSLBCHE | |
| SCHEMBL12368238 | 0.80 | IMPDH2 (0.49) | IMPDH2IMPDH1CTSLBCHE | |
| SCHEMBL12368240 | 0.80 | IMPDH2 (0.51) | IMPDH2IMPDH1CTSLBCHE | |
| SCHEMBL13202467 | 0.79 | BCHE (0.53) | IMPDH2IMPDH1CTSLBCHE | |
| SCHEMBL14518603 | 0.79 | IMPDH2 (0.52) | IMPDH2IMPDH1CTSLALDH1A1BCHE | |
| SCHEMBL12368233 | 0.77 | IMPDH2 (0.82) | IMPDH2IMPDH1 | |
| SCHEMBL14543430 | 0.76 | IMPDH2 (0.50) | IMPDH2IMPDH1CTSLBCHE | |
| SCHEMBL2969565 | 0.75 | BCHE (0.53) | IMPDH2IMPDH1ALDH1A1BCHEMAPT | |
| SCHEMBL2969563 | 0.75 | BCHE (0.53) | IMPDH2IMPDH1ALDH1A1BCHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777048-B2 | Processes for preparing biaryl ureas and analogs thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090221835-A1 | PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2009-09-03 | — | — | US | disclosed |
| US-7544810-B2 | Processes for preparing biaryl ureas and analogs thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-09 | — | — | US | disclosed |
| US-20080021222-A1 | Processes for preparing biaryl ureas and analogs thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021222-A1 | Processes for preparing biaryl ureas and analogs thereof | IMPDH1, IMPDH2, UGDH | IMPDH2 2/4885IMPDH1 1/4885CTSL 2683/4885 |
| US-20090221835-A1 | PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF | IMPDH1, IMPDH2, UGDH | IMPDH2 2/4885IMPDH1 1/4885CTSL 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.