Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26613338 | 1.00 | KDM4E (0.50) | KDM4EGAAHPGDALDH1A1HSD17B10 | |
| SCHEMBL19788566 | 0.81 | NR2E3 (0.46) | KDM4EHPGDALDH1A1MEN1LMNA | |
| SCHEMBL26613353 | 0.80 | MAPT (0.46) | KDM4EALDH1A1HSD17B10MEN1LMNA | |
| SCHEMBL29745812 | 0.80 | MAPT (0.46) | KDM4EALDH1A1HSD17B10MEN1LMNA | |
| SCHEMBL28467771 | 0.80 | ESR1 (0.48) | KDM4ECYP2D6ESR1ESR2 | |
| SCHEMBL28467773 | 0.80 | ESR1 (0.48) | KDM4ECYP2D6ESR1ESR2 | |
| SCHEMBL18466556 | 0.79 | ALDH1A1 (0.43) | KDM4EGAAHPGDALDH1A1HSD17B10 | |
| SCHEMBL18882748 | 0.77 | ESR1 (0.39) | KDM4EGAAHPGDALDH1A1HSD17B10 | |
| SCHEMBL28900574 | 0.75 | ESR1 (0.47) | GAAALDH1A1HTTESR1ESR2 | |
| SCHEMBL18755234 | 0.75 | ESR1 (0.47) | GAAALDH1A1HTTESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119403554-A | Therapeutic or prophylactic agent for amyotrophic lateral sclerosis | 东丽株式会社 | 2025-02-07 | — | — | CN | disclosed |
| CN-116648245-A | Tetrahydroquinoline derivative and medical application thereof | 东丽株式会社 | 2023-08-25 | — | — | CN | disclosed |
| WO-2022138888-A1 | TETRAHYDROQUINOLINE DERIVATIVE AND MEDICINAL USE THEREOF | 東レ株式会社 | 2022-06-30 | — | — | WO | disclosed |