Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PSMB8 | P28062 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699050 | 1.00 | KDM4E (1.00) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL12716526 | 0.91 | KDM4E (0.82) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL4703352 | 0.86 | KDM4E (0.75) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL17260645 | 0.79 | PDE3B (0.71) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL97140 | 0.74 | PSMB8 (1.00) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL30834681 | 0.74 | PSMB8 (1.00) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL10897160 | 0.73 | PSMB8 (0.63) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL21613695 | 0.72 | KDM4E (0.56) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL4704344 | 0.72 | PSMB8 (0.61) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL14403384 | 0.72 | PSMB8 (0.72) | KDM4EGAAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220257583-A1 | Compositions and Methods for the Treatment of Intracranial Diseases | UNIV DUKE (US) | 2022-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220257583-A1 | Compositions and Methods for the Treatment of Intracranial Diseases | S1PR1, S1PR3, S1PR2 | KDM4E 4048/4885GAA 2875/4885MEN1 306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.