Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30828338 | 0.80 | HPGD (0.55) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL28195169 | 0.76 | HPGD (0.62) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL20446072 | 0.75 | HPGD (0.51) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL28195170 | 0.75 | HPGD (0.58) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL28194650 | 0.74 | HPGD (0.59) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL28254369 | 0.72 | HPGD (0.57) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL28194606 | 0.71 | HPGD (0.56) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL28254374 | 0.70 | HPGD (0.55) | HPGDTRPM8TSHRRAB9APOLB | |
| SCHEMBL26964344 | 0.69 | TRPM8 (0.78) | TRPM8 | |
| SCHEMBL28194603 | 0.68 | TSHR (0.53) | HPGDTRPM8TSHRRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291553-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | Givaudan SA (CH) | 2023-12-20 | — | — | EP | claimed |
| WO-2022170519-A1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2022-08-18 | — | — | WO | claimed |
| WO-2022171653-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | GIVAUDAN SA (CH) | 2022-08-18 | — | — | WO | claimed |