Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.63 |
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2974 | 1.00 | AGTR1 (0.63) | AGTR1LTB4R2ABCB11GP6HDAC3 | |
| SCHEMBL1512 | 0.92 | AGTR1 (0.75) | AGTR1LTB4R2ABCB11GP6HDAC3 | |
| SCHEMBL1511 | 0.92 | AGTR1 (0.75) | AGTR1LTB4R2ABCB11GP6HDAC3 | |
| SCHEMBL2377 | 0.89 | AGTR1 (0.57) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2378 | 0.89 | AGTR1 (0.57) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL3439 | 0.88 | AGTR1 (0.57) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL3438 | 0.88 | AGTR1 (0.57) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2381 | 0.88 | AGTR1 (0.60) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2382 | 0.88 | AGTR1 (0.60) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL683473 | 0.84 | AGTR1 (0.61) | AGTR1LTB4R2ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | claimed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | claimed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |