Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.55 |
| ▸ | AURKA | O14965 | 7/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | PAK4 | O96013 | 2/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | PRKCG | P05129 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28778545 | 1.00 | SYK (0.55) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1275642 | 0.86 | SYK (0.72) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1476160 | 0.82 | SYK (0.62) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1474827 | 0.82 | SYK (0.59) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1474610 | 0.82 | SYK (0.58) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1474611 | 0.81 | SYK (0.57) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1474794 | 0.79 | SYK (0.67) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL12902019 | 0.79 | SYK (0.62) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1473228 | 0.79 | EGFR (0.62) | SYKAURKACDK2AURKBEGFR | |
| SCHEMBL1607189 | 0.78 | JAK3 (0.60) | SYKAURKACDK2AURKBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114698370-A | Compounds and methods for treating cytokine release syndrome | 里格尔药品股份有限公司 | 2022-07-01 | — | — | CN | disclosed |