Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 18/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 18/20 | 0.56 |
| ▸ | EIF4E | P06730 | 9/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625999 | 1.00 | MKNK1 (0.56) | MKNK1MKNK2EIF4ECYP3A4HPGD | |
| SCHEMBL16621123 | 0.87 | MKNK1 (0.58) | MKNK1MKNK2EIF4ECYP3A4HPGD | |
| SCHEMBL29756259 | 0.87 | MKNK1 (0.58) | MKNK1MKNK2EIF4ECYP3A4HPGD | |
| SCHEMBL17969585 | 0.87 | MKNK1 (0.56) | MKNK1MKNK2EIF4ECYP3A4HPGD | |
| SCHEMBL16626027 | 0.84 | MKNK1 (0.58) | MKNK1MKNK2EIF4ECYP3A4HPGD | |
| SCHEMBL29756302 | 0.84 | MKNK1 (0.58) | MKNK1MKNK2EIF4ECYP3A4HPGD | |
| SCHEMBL16620565 | 0.82 | MKNK1 (0.53) | MKNK1MKNK2EIF4ECYP3A4KCNH2 | |
| SCHEMBL29756334 | 0.82 | MKNK1 (0.53) | MKNK1MKNK2EIF4ECYP3A4KCNH2 | |
| SCHEMBL16621118 | 0.82 | MKNK1 (0.64) | MKNK1MKNK2EIF4ECYP3A4HPGD | |
| SCHEMBL29756286 | 0.82 | MKNK1 (0.64) | MKNK1MKNK2EIF4ECYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052501-B1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2022-06-22 | — | — | EP | disclosed |