Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122816 | 1.00 | DYRK1A (0.49) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL31714573 | 0.90 | DYRK1A (0.51) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL20122717 | 0.90 | DYRK1A (0.51) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL20122962 | 0.83 | MAOA (0.56) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL29756413 | 0.81 | MAOA (0.54) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL20122797 | 0.81 | MAOA (0.54) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL20122918 | 0.81 | MAOA (0.54) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL29756312 | 0.81 | MAOA (0.54) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL20122742 | 0.78 | MAOA (0.51) | DYRK1AMAOAACHEKDM4EDYRK3 | |
| SCHEMBL29756357 | 0.78 | MAOA (0.51) | DYRK1AMAOAACHEKDM4EDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110382496-B | Substituted pyrido [3,4-b ] indoles for the treatment of cartilage disorders | 赛诺菲 | 2022-08-09 | — | — | CN | disclosed |