Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22968514 | 1.00 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL23067814 | 1.00 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL23085727 | 0.92 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL22968519 | 0.90 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL22968520 | 0.89 | RIPK1 (0.54) | RIPK1 | |
| SCHEMBL23085730 | 0.89 | RIPK1 (0.54) | RIPK1 | |
| SCHEMBL22968517 | 0.89 | RIPK1 (0.54) | RIPK1 | |
| SCHEMBL23075318 | 0.85 | RIPK1 (0.64) | RIPK1 | |
| SCHEMBL22968464 | 0.80 | RIPK1 (0.54) | RIPK1 | |
| SCHEMBL22968463 | 0.80 | RIPK1 (0.58) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120192310-A | Benzene as RIPK1 inhibitor and oxazepine compounds | 南京天印健华医药科技有限公司 | 2025-06-24 | — | — | CN | disclosed |
| CN-114728918-B | RIP1 inhibitory compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2025-06-17 | — | — | CN | disclosed |
| CN-114728958-B | RIP1 inhibitory compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2025-05-02 | — | — | CN | disclosed |
| CN-114761398-B | Heterocyclic RIP1 kinase inhibitors | 里格尔药品股份有限公司 | 2025-03-11 | — | — | CN | disclosed |
| EP-4304713-A1 | HETEROCYCLIC RIP1 KINASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192533-A1 | HETEROCYCLIC RIP1 KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2022-09-15 | — | — | WO | disclosed |
| CN-114761398-A | Heterocyclic RIP1 kinase inhibitors | 里格尔药品股份有限公司 | 2022-07-15 | — | — | CN | disclosed |
| EP-4025575-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2022-07-13 | — | — | EP | disclosed |
| EP-4025572-A1 | HETEROCYCLIC RIP1 KINASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2022-07-13 | — | — | EP | disclosed |
| EP-4025574-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2022-07-13 | — | — | EP | disclosed |
| CN-114728918-A | RIP1 inhibiting compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2022-07-08 | — | — | CN | disclosed |