Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22025609 | 1.00 | EGFR (0.49) | EGFRINSRIGF1RALKCDK7 | |
| SCHEMBL22026203 | 0.89 | EGFR (0.45) | EGFR | |
| SCHEMBL30748540 | 0.89 | EGFR (0.45) | EGFR | |
| SCHEMBL22595311 | 0.89 | EGFR (0.51) | EGFRINSRIGF1RALKCDK9 | |
| SCHEMBL22025651 | 0.88 | EGFR (0.49) | EGFR | |
| SCHEMBL29747109 | 0.88 | EGFR (0.49) | EGFR | |
| SCHEMBL30018877 | 0.88 | EGFR (0.40) | EGFRINSRIGF1RALKCDK9 | |
| SCHEMBL22595435 | 0.88 | EGFR (0.40) | EGFRINSRIGF1RALKCDK9 | |
| SCHEMBL30018602 | 0.86 | EGFR (0.49) | EGFR | |
| SCHEMBL28609013 | 0.86 | EGFR (0.49) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888108-B | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117425646-A | Phosphono derivative, composition thereof and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-116888108-A | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-113166103-B | EGFR inhibitor and application thereof | 江苏先声药业有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-114728932-A | Polyarylates as EGFR kinase inhibitors | 江苏先声药业有限公司 | 2022-07-08 | — | — | CN | disclosed |