Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963177 | 0.96 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAALDH1A1MAOBGAA | |
| SCHEMBL2961916 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAALDH1A1MAOBGAA | |
| SCHEMBL2969262 | 0.86 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNAALDH1A1MAOBGAA | |
| SCHEMBL3579943 | 0.84 | KMT2A (0.40) | SMN1; SMN2LMNAALDH1A1MAPTPOLB | |
| SCHEMBL366030 | 0.83 | KMT2A (0.41) | LMNAALDH1A1GAAMAPTPKM | |
| SCHEMBL13338197 | 0.81 | TDP1 (0.42) | LMNAALDH1A1GAAMAPTPOLB | |
| SCHEMBL15574722 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1MAOBGAA | |
| SCHEMBL15574830 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAALDH1A1MAOBGAA | |
| SCHEMBL13338199 | 0.80 | TDP1 (0.40) | LMNAALDH1A1GAAMAPTPOLB | |
| SCHEMBL3685958 | 0.79 | MEN1 (0.36) | SMN1; SMN2ALDH1A1GAAMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776924-B2 | Nitroaniline-based alkylating agents and their use as prodrugs | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-08-17 | — | — | US | disclosed |
| US-20050256191-A1 | Nitroaniline-based alkylating agents and their use as prodrugs | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256191-A1 | Nitroaniline-based alkylating agents and their use as prodrugs | IDH3A, HIF1AN, IDH1 | SMN1; SMN2 2843/4885LMNA 3875/4885ALDH1A1 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.