Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185248 | 1.00 | MAPK14 (0.34) | MAPK14CHRM1PDGFRAHRH3GAA | |
| SCHEMBL29759568 | 0.89 | ALDH1A1 (0.38) | CHRM1PDGFRAHRH3ALDH1A1TYK2 | |
| SCHEMBL24577737 | 0.89 | ALDH1A1 (0.38) | CHRM1PDGFRAHRH3ALDH1A1TYK2 | |
| SCHEMBL29759753 | 0.88 | IRAK4 (0.31) | CHRM1PDGFRAHRH3ALDH1A1TYK2 | |
| SCHEMBL29759657 | 0.88 | KDM1A (0.35) | CHRM1PDGFRAHRH3GAACSF1R | |
| SCHEMBL24579053 | 0.88 | KDM1A (0.35) | CHRM1PDGFRAHRH3GAACSF1R | |
| SCHEMBL29759739 | 0.85 | EPHB3 (0.34) | CHRM1PDGFRAHRH3TYK2CSF1R | |
| SCHEMBL29759822 | 0.84 | ALDH1A1 (0.34) | CHRM1PDGFRAHRH3GAAALDH1A1 | |
| SCHEMBL29759664 | 0.84 | MEN1 (0.36) | CHRM1PDGFRAHRH3GAAALDH1A1 | |
| SCHEMBL27185086 | 0.84 | MEN1 (0.36) | CHRM1PDGFRAHRH3GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |