Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24579022 | 1.00 | POLQ (0.39) | POLQRORCIRAK4GPR6CCNT1 | |
| SCHEMBL24577573 | 0.89 | POLQ (0.40) | POLQIRAK4GPR6CCNT1CDK9 | |
| SCHEMBL24579021 | 0.87 | POLQ (0.40) | POLQIRAK4GPR6CCNT1CDK9 | |
| SCHEMBL29759526 | 0.86 | POLQ (0.37) | POLQIRAK4GPR6CCNT1CDK9 | |
| SCHEMBL27184973 | 0.86 | POLQ (0.37) | POLQIRAK4GPR6CCNT1CDK9 | |
| SCHEMBL24577845 | 0.86 | POLQ (0.33) | POLQIRAK4CCNT1CDK9 | |
| SCHEMBL24577397 | 0.86 | POLQ (0.37) | POLQIRAK4GPR6CCNT1CDK9 | |
| SCHEMBL29759540 | 0.85 | POLQ (0.37) | POLQIRAK4GPR6CCNT1CDK9 | |
| SCHEMBL29760033 | 0.85 | POLQ (0.37) | POLQIRAK4GPR6CCNT1CDK9 | |
| SCHEMBL24577376 | 0.85 | POLQ (0.37) | POLQIRAK4GPR6CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |