Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.40 |
| ▸ | JAK3 | P52333 | 11/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.37 |
| ▸ | TYK2 | P29597 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759991 | 0.85 | MKNK1 (0.46) | JAK1JAK3JAK2TYK2PKN1 | |
| SCHEMBL30566450 | 0.85 | MKNK1 (0.46) | JAK1JAK3JAK2TYK2PKN1 | |
| SCHEMBL29760263 | 0.84 | CDC7 (0.43) | JAK1JAK3JAK2TYK2CHUK | |
| SCHEMBL24576870 | 0.81 | MKNK1 (0.41) | JAK1JAK3TYK2KCNH2MKNK1 | |
| SCHEMBL24576965 | 0.81 | CHEK1 (0.37) | JAK1JAK3JAK2TYK2IKBKB | |
| SCHEMBL30566577 | 0.81 | RIPK2 (0.32) | JAK1JAK3JAK2TYK2RIPK2 | |
| Hydrochloric Acid SCHEMBL30566474 | 0.80 | MKNK1 (0.41) | JAK1JAK3TYK2KCNH2MKNK1 | |
| Hydrochloric Acid SCHEMBL29759885 | 0.80 | CHEK1 (0.37) | JAK1JAK3JAK2TYK2IKBKB | |
| SCHEMBL24578221 | 0.79 | RIPK2 (0.33) | JAK1JAK3JAK2TYK2RIPK2 | |
| SCHEMBL30566465 | 0.79 | RIPK2 (0.33) | JAK1JAK3JAK2TYK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |