Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576870 | 0.86 | MKNK1 (0.41) | JAK1TYK2JAK3CHEK1MKNK1 | |
| Hydrochloric Acid SCHEMBL30566474 | 0.85 | MKNK1 (0.41) | JAK1TYK2JAK3CHEK1MKNK1 | |
| SCHEMBL29759773 | 0.81 | JAK1 (0.40) | RIPK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30566568 | 0.81 | JAK1 (0.35) | RIPK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30566490 | 0.80 | PDK2 (0.41) | JAK2JAK1JAK3 | |
| SCHEMBL30566512 | 0.80 | JAK3 (0.38) | JAK2JAK1TYK2JAK3MKNK1 | |
| SCHEMBL29760263 | 0.80 | CDC7 (0.43) | RIPK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL24576965 | 0.78 | CHEK1 (0.37) | RIPK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL30566450 | 0.77 | MKNK1 (0.46) | JAK2JAK1TYK2JAK3MKNK1 | |
| Hydrochloric Acid SCHEMBL29759885 | 0.77 | CHEK1 (0.37) | RIPK2JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |