Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 5/20 | 0.32 |
| ▸ | JAK3 | P52333 | 5/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577570 | 0.89 | CCNT1 (0.36) | CCNT1CDK9 | |
| SCHEMBL24576986 | 0.84 | BACE1 (0.37) | CDK9 | |
| SCHEMBL29759980 | 0.79 | POLQ (0.34) | ACVR1CCNT1CDK9 | |
| SCHEMBL29759926 | 0.78 | CCNT1 (0.36) | CCNT1CDK9 | |
| SCHEMBL24577437 | 0.78 | CCNT1 (0.36) | CCNT1CDK9 | |
| SCHEMBL28975929 | 0.78 | KDM4E (0.35) | ACVR1CCNT1CDK9JAK1JAK3 | |
| Hydrochloric Acid SCHEMBL29760151 | 0.78 | CCNT1 (0.35) | CCNT1CDK9 | |
| SCHEMBL24577427 | 0.76 | IRAK4 (0.38) | CCNT1CDK9 | |
| SCHEMBL24579066 | 0.76 | CCNT1 (0.35) | CCNT1CDK9 | |
| SCHEMBL29759922 | 0.76 | CCNT1 (0.35) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |