Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 4/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760058 | 0.84 | ACVR1 (0.33) | CDK9 | |
| SCHEMBL29759980 | 0.81 | POLQ (0.34) | POLQCDK9 | |
| SCHEMBL24577500 | 0.75 | POLQ (0.42) | BACE1POLQCDK9KIT | |
| SCHEMBL28975942 | 0.75 | CYP11B2 (0.39) | CYP11B1CYP11B2CDK9 | |
| SCHEMBL24579054 | 0.74 | POLQ (0.44) | BACE1POLQCDK9KIT | |
| SCHEMBL30566551 | 0.73 | MKNK1 (0.40) | CYP11B2 | |
| SCHEMBL24577570 | 0.73 | CCNT1 (0.36) | CDK9 | |
| SCHEMBL25172258 | 0.71 | HTR2A (0.43) | CYP11B1CYP11B2POLQCDK9 | |
| SCHEMBL29759849 | 0.71 | TYK2 (0.33) | — | |
| SCHEMBL24576870 | 0.70 | MKNK1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |