Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875670 | 1.00 | PIK3CA (0.57) | PIK3CALRRK2KMOPIK3CDSMG1 | |
| SCHEMBL20600825 | 0.85 | HRH4 (0.47) | PIK3CALRRK2SMN1; SMN2 | |
| SCHEMBL29957346 | 0.85 | HRH4 (0.44) | PIK3CALRRK2SMN1; SMN2 | |
| SCHEMBL12814899 | 0.83 | HRH4 (0.50) | PIK3CALRRK2SMG1SMN1; SMN2ALDH1A1 | |
| SCHEMBL29955150 | 0.83 | HRH4 (0.50) | PIK3CALRRK2SMG1SMN1; SMN2ALDH1A1 | |
| SCHEMBL29375965 | 0.81 | HRH4 (0.55) | CYP2C19KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1602821 | 0.81 | ADRB1 (0.55) | KDM4EALDH1A1 | |
| SCHEMBL29956812 | 0.81 | ADRB1 (0.55) | KDM4EALDH1A1 | |
| SCHEMBL721503 | 0.81 | HRH4 (0.55) | CYP2C19KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL247930 | 0.80 | PIK3CA (0.64) | PIK3CALRRK2KMOPIK3CDSMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |