Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006546 | 1.00 | TSHR (0.48) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL28825412 | 0.86 | ALDH1A1 (0.47) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL31597058 | 0.86 | ALDH1A1 (0.47) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL25337052 | 0.86 | ALDH1A1 (0.47) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL27831883 | 0.85 | TSHR (0.47) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL597893 | 0.85 | TDP1 (0.50) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL1564582 | 0.83 | ALDH1A1 (0.44) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL19204031 | 0.83 | ALDH1A1 (0.41) | TSHRALDH1A1CYP3A4RECQLGAA | |
| SCHEMBL8483314 | 0.83 | ALDH1A1 (0.42) | TSHRALDH1A1CYP3A4RECQLGAA | |
| Ammonia Solution, Strong SCHEMBL25335787 | 0.83 | ALDH1A1 (0.44) | TSHRALDH1A1CYP3A4RECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |