Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28316678 | 1.00 | HRH3 (0.51) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL29759987 | 1.00 | HRH3 (0.51) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL24951714 | 0.96 | ACHE (0.53) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL24951474 | 0.96 | ACHE (0.53) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL18851285 | 0.91 | ACHE (0.54) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL18233673 | 0.85 | EPHX1 (0.45) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL18851365 | 0.83 | EPHX1 (0.46) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL18851364 | 0.83 | EPHX1 (0.46) | HRH3ACHEBACE1EPHX1MEN1 | |
| SCHEMBL20545129 | 0.83 | EPHX1 (0.46) | HRH3EPHX1MEN1KMT2ATSHR | |
| SCHEMBL17625378 | 0.83 | EPHX1 (0.46) | HRH3ACHEBACE1EPHX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |