Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 6/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | SIK1 | P57059 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809563 | 0.91 | PDGFRA (0.38) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL29759699 | 0.89 | IKBKE (0.48) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24578823 | 0.89 | IKBKE (0.48) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24578953 | 0.88 | IKBKE (0.44) | IKBKETBK1PDGFRACHRM1HRH3 | |
| Hydrochloric Acid SCHEMBL29759717 | 0.88 | IKBKE (0.47) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24577482 | 0.88 | IKBKE (0.43) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24577574 | 0.87 | PDGFRA (0.46) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL30809475 | 0.86 | PDGFRA (0.37) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL24577285 | 0.85 | IKBKE (0.42) | IKBKETBK1PDGFRACHRM1HRH3 | |
| SCHEMBL29759532 | 0.85 | IKBKE (0.42) | IKBKETBK1PDGFRACHRM1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |