Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 7/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809563 | 0.92 | PDGFRA (0.38) | PDGFRACHRM1HRH3IKBKETBK1 | |
| SCHEMBL29760255 | 0.86 | IKBKE (0.44) | PDGFRACHRM1HRH3IKBKETBK1 | |
| SCHEMBL24577201 | 0.83 | LMNA (0.39) | PDGFRACHRM1HRH3IKBKETBK1 | |
| SCHEMBL24577136 | 0.82 | PDGFRA (0.45) | PDGFRACHRM1HRH3MAPK14IRAK4 | |
| SCHEMBL24578823 | 0.82 | IKBKE (0.48) | PDGFRACHRM1HRH3IKBKETBK1 | |
| SCHEMBL29759699 | 0.82 | IKBKE (0.48) | PDGFRACHRM1HRH3IKBKETBK1 | |
| SCHEMBL24578953 | 0.81 | IKBKE (0.44) | PDGFRACHRM1HRH3IKBKETBK1 | |
| Hydrochloric Acid SCHEMBL29759717 | 0.81 | IKBKE (0.47) | PDGFRACHRM1HRH3IKBKETBK1 | |
| SCHEMBL24578901 | 0.80 | STING1 (0.36) | PDGFRACHRM1HRH3STING1MAPK14 | |
| SCHEMBL24577098 | 0.80 | IKBKE (0.42) | PDGFRACHRM1HRH3IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |