Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614317 | 0.86 | PDE4D (0.56) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL353564 | 0.83 | PDE4D (1.00) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL23013132 | 0.83 | PDE4D (0.53) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL3262021 | 0.81 | PDE4D (0.51) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL23122563 | 0.81 | PDE4D (0.51) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL7513038 | 0.80 | PDE4D (0.73) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL31367819 | 0.80 | PDE4D (0.73) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL20583553 | 0.79 | PDE4D (0.49) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL23001765 | 0.79 | PDE4D (0.71) | PDE4DMAPTKDM4EPOLBKMT2A | |
| SCHEMBL600955 | 0.79 | PDE4D (0.71) | PDE4DMAPTKDM4EPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288435-A1 | TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS | Amgen Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| EP-4263545-A1 | PRMTS INHIBITORS | Amgen Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022169948-A1 | TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| WO-2022132914-A1 | PRMTS INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | WO | disclosed |