Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | FHIT | P49789 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942577 | 0.86 | PDE4D (0.56) | PDE4DSMN1; SMN2HTTMAPK10KDM4E | |
| SCHEMBL11160154 | 0.84 | SMN1; SMN2 (0.55) | PDE4DSMN1; SMN2HTTMAPK10KDM4E | |
| SCHEMBL353564 | 0.83 | PDE4D (1.00) | PDE4DSMN1; SMN2MAPK10KDM4EMAPT | |
| SCHEMBL17781303 | 0.83 | SMN1; SMN2 (0.53) | PDE4DSMN1; SMN2HTTMAPK10KDM4E | |
| SCHEMBL20709978 | 0.83 | SMN1; SMN2 (0.53) | PDE4DSMN1; SMN2HTTMAPK10KDM4E | |
| SCHEMBL11472383 | 0.81 | GAA (0.49) | PDE4DSMN1; SMN2HTTMAPK10MAPT | |
| SCHEMBL22768839 | 0.81 | SMN1; SMN2 (0.52) | PDE4DSMN1; SMN2HTTMAPK10KDM4E | |
| SCHEMBL2084577 | 0.80 | SMN1; SMN2 (0.51) | PDE4DSMN1; SMN2HTTMAPK10KDM4E | |
| SCHEMBL7513038 | 0.80 | PDE4D (0.73) | PDE4DSMN1; SMN2MAPK10KDM4EMAPT | |
| SCHEMBL31367819 | 0.80 | PDE4D (0.73) | PDE4DSMN1; SMN2MAPK10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | claimed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | claimed |
| US-20250353864-A1 | INDAZOLE CONTAINING MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS INC (US) | 2025-11-20 | — | — | US | disclosed |
| US-20250186441-A1 | COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES | OXALURX, INC. | 2025-06-12 | — | — | US | disclosed |
| EP-4536224-A1 | INDAZOLE CONTAINING MACROCYCLES AND THEIR USE | Blossomhill Therapeutics, Inc. (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119421709-A | Indazole-containing macrocyclic compounds and uses thereof | 荣山医药股份有限公司 | 2025-02-11 | — | — | CN | disclosed |
| US-12213976-B2 | Compounds and methods for treating oxalate-related diseases | OXALURX, INC. (US) | 2025-02-04 | — | — | US | disclosed |
| CN-114980886-B | Compounds and methods for treating oxalate-related diseases | 奥沙鲁克斯公司 | 2024-08-09 | — | — | CN | disclosed |
| US-11944626-B2 | Small molecule inhibitors of ALDH and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3471712-B1 | SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF | UNIV MICHIGAN REGENTS (US) | 2024-01-03 | — | — | EP | disclosed |
| WO-2023240138-A1 | INDAZOLE CONTAINING MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| US-20050256130-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2005-11-17 | — | — | US | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| EP-1531822-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | Chemocentryx, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| US-20040162282-A1 | Substituted piperazines | CHEMOCENTRYX, INC. | 2004-08-19 | — | — | US | disclosed |
| US-20040082571-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2004-04-29 | — | — | US | disclosed |
| WO-2003105853-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | CHEMOCENTRYX, INC. (US) | 2003-12-24 | — | — | WO | disclosed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4281000-A | Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents | AMERICAN CYANAMID COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0025819-A1 | Substituted pyrazolo (1,5-a) pyrimidines, and their preparation | AMERICAN CYANAMID COMPANY (US) | 1981-04-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082571-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | PDE4D 3600/4885SMN1; SMN2 1035/4885HTT 3106/4885 |
| US-20250353864-A1 | INDAZOLE CONTAINING MACROCYCLES AND THEIR USE | AADAC, PAICS, CYP3A43 | PDE4D 1361/4885SMN1; SMN2 2592/4885HTT 1174/4885 |
| US-20050256130-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | PDE4D 2673/4885SMN1; SMN2 1026/4885HTT 3478/4885 |
| US-11944626-B2 | Small molecule inhibitors of ALDH and uses thereof | ALDH2, ALDH1A1, ALDH3A1 | PDE4D 1846/4885SMN1; SMN2 3775/4885HTT 2698/4885 |
| US-20250186441-A1 | COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES | XDH, PNPO, OAT | PDE4D 1661/4885SMN1; SMN2 3115/4885HTT 2349/4885 |
| US-20040162282-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | PDE4D 3600/4885SMN1; SMN2 1035/4885HTT 3106/4885 |
| US-12213976-B2 | Compounds and methods for treating oxalate-related diseases | XDH, PNPO, OAT | PDE4D 1661/4885SMN1; SMN2 3115/4885HTT 2349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.