Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245771 | 1.00 | MAPT (0.61) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL17204101 | 0.87 | MAPT (0.61) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL20267260 | 0.83 | MAPT (0.61) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL30068134 | 0.83 | MAPT (0.61) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL29434160 | 0.82 | MAPT (0.65) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL971891 | 0.82 | MAPT (0.65) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL29434159 | 0.82 | MAPT (0.65) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL14024999 | 0.82 | MAPT (0.56) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL29713891 | 0.81 | HRH4 (0.59) | MAPTCYP1A2CYP2D6CRHBPCRHR2 | |
| SCHEMBL3634340 | 0.81 | HRH4 (0.59) | MAPTCYP1A2CYP2D6CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472968-A1 | INHIBITORS OF RAF KINASES | PIERRE FABRE MEDICAMENT (FR) | 2024-12-11 | — | — | EP | disclosed |
| CN-118974036-A | Inhibitors of RAF kinase | 皮埃尔法布雷医药公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-114845711-B | Inhibitors of RAF kinase | 皮埃尔法布雷医药公司 | 2024-10-01 | — | — | CN | disclosed |
| WO-2023150681-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2023-08-10 | — | — | WO | disclosed |
| CN-114845711-A | Inhibitors of RAF kinase | 金耐特生物制药公司 | 2022-08-02 | — | — | CN | disclosed |