Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.32 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.32 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL2976304 | 1.00 | SLC7A5 (0.36) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL20678156 | 0.95 | SLC7A5 (0.39) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL7521151 | 0.95 | SLC7A5 (0.39) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL22769647 | 0.95 | SLC7A5 (0.39) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL3967555 | 0.95 | SLC7A5 (0.39) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL27673609 | 0.90 | SLC7A5 (0.36) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL2763245 | 0.89 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL1136528 | 0.89 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL56857 | 0.89 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 | |
| Histidine SCHEMBL8027991 | 0.89 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2GRIA2GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080190894-A1 | Chemical Mechanical Polishing Slurries, Their Applications and Method of Use Thereof | ANJI MICROELECTRONICS (SHANGHAI) CO., LTD. (CN) | 2008-08-14 | — | — | US | claimed |
| US-7776231-B2 | Chemical mechanical polishing slurries, their applications and method of use thereof | ANJI MICROELECTRONICS (SHANGHAI) CO., LTD. (CN) | 2010-08-17 | — | — | US | disclosed |
| US-20080190894-A1 | Chemical Mechanical Polishing Slurries, Their Applications and Method of Use Thereof | ANJI MICROELECTRONICS (SHANGHAI) CO., LTD. (CN) | 2008-08-14 | — | — | US | disclosed |