⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24566482 | 1.00 | — | — | |
| SCHEMBL24566481 | 1.00 | — | — | |
| SCHEMBL24815068 | 0.85 | — | — | |
| SCHEMBL24007985 | 0.80 | — | — | |
| SCHEMBL24815033 | 0.79 | KDM1A (0.30) | — | |
| SCHEMBL24007989 | 0.78 | KDM1A (0.33) | — | |
| SCHEMBL24007988 | 0.78 | KDM1A (0.33) | — | |
| SCHEMBL26012056 | 0.78 | — | — | |
| SCHEMBL24007920 | 0.76 | — | — | |
| SCHEMBL29762801 | 0.76 | CYP11B2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267574-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |