Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12755285 | 0.79 | KDM4E (0.51) | HPGDKDM4ENQO2ALDH1A1CYP19A1 | |
| SCHEMBL15186918 | 0.76 | EGFR (0.33) | HPGDKDM4EEGFRCSF1R | |
| SCHEMBL20577550 | 0.74 | KDM4E (0.43) | HPGDKDM4EEGFRCSF1RALDH1A1 | |
| SCHEMBL12755300 | 0.74 | KDM4E (0.40) | HPGDKDM4ENQO2ALDH1A1CYP19A1 | |
| SCHEMBL12829337 | 0.74 | HPGD (0.43) | HPGDKDM4ENQO2ALDH1A1 | |
| SCHEMBL29763553 | 0.74 | KDM4E (0.40) | HPGDKDM4ENQO2ALDH1A1CYP19A1 | |
| SCHEMBL22139831 | 0.73 | EGFR (0.36) | EGFRCSF1RALDH1A1 | |
| SCHEMBL593723 | 0.73 | KDM4E (0.45) | HPGDKDM4ECSF1RNQO2ALDH1A1 | |
| SCHEMBL12118481 | 0.73 | EGFR (0.36) | EGFRCSF1RALDH1A1 | |
| SCHEMBL5779840 | 0.72 | IDO1 (0.49) | EGFRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288424-A1 | NOVEL HETEROARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022167631-A1 | NOVEL HETEROARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-08-11 | — | — | WO | disclosed |