Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24610141 | 1.00 | ALDH1A1 (0.43) | ALDH1A1NPSR1TDP1HTTSMN1; SMN2 | |
| SCHEMBL20471960 | 0.85 | TSHR (0.44) | ALDH1A1NPSR1TDP1HTTSMN1; SMN2 | |
| SCHEMBL29765192 | 0.85 | TSHR (0.40) | ALDH1A1NPSR1TDP1HTTSMN1; SMN2 | |
| SCHEMBL24610200 | 0.85 | TSHR (0.40) | ALDH1A1NPSR1TDP1HTTSMN1; SMN2 | |
| SCHEMBL1235983 | 0.85 | HDAC3 (0.52) | HDAC3HDAC1HDAC2NCOR2BACE1 | |
| SCHEMBL24324611 | 0.85 | HDAC3 (0.52) | HDAC3HDAC1HDAC2NCOR2BACE1 | |
| SCHEMBL15311357 | 0.85 | HDAC3 (0.52) | HDAC3HDAC1HDAC2NCOR2BACE1 | |
| SCHEMBL23995941 | 0.84 | HDAC3 (0.40) | ALDH1A1NPSR1TDP1HTTSMN1; SMN2 | |
| SCHEMBL29765190 | 0.84 | HDAC3 (0.40) | ALDH1A1NPSR1TDP1HTTSMN1; SMN2 | |
| SCHEMBL20472046 | 0.83 | ALDH1A1 (0.52) | ALDH1A1NPSR1TDP1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580224-B1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2022-07-13 | — | — | EP | disclosed |