Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pf-03049423. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A known ✓ | O76074 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | PDE6A | P16499 | 5/20 | 0.70 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pf-03049423 SCHEMBL1969224 | 1.00 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| Pf-03049423 SCHEMBL29357029 | 1.00 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1973676 | 0.97 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1973153 | 0.96 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1970086 | 0.93 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1971532 | 0.93 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1968969 | 0.91 | PDE5A (0.84) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1970644 | 0.91 | PDE5A (0.84) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970611 | 0.91 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970610 | 0.91 | PDE5A (1.00) | PDE5AKCNH2PDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220244263-A1 | METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-08-04 | — | — | US | disclosed |