Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pf-03049423. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A known ✓ | O76074 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | PDE6A | P16499 | 5/20 | 0.70 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pf-03049423 SCHEMBL1969224 | 1.00 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| Pf-03049423 SCHEMBL29766850 | 1.00 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1973676 | 0.97 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1973153 | 0.96 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1970086 | 0.93 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1971532 | 0.93 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1968969 | 0.91 | PDE5A (0.84) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1970644 | 0.91 | PDE5A (0.84) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970611 | 0.91 | PDE5A (1.00) | PDE5AKCNH2PDE6A | |
| SCHEMBL1970610 | 0.91 | PDE5A (1.00) | PDE5AKCNH2PDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 582 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257316-A1 | CONTROL OF NITROGEN FIXATION IN RHIZOBIA THAT ASSOCIATE WITH CEREALS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2025-08-14 | — | — | US | claimed |
| CN-115160390-B | Stilbene glucoside dimer compound and preparation method and application thereof | 中国食品药品检定研究院 | 2024-02-02 | — | — | CN | claimed |
| CN-115385604-A | SiO (silicon dioxide) 2 Aerogel composite needled felt, preparation method and application | 南通大学 | 2022-11-25 | — | — | CN | claimed |
| CN-115160390-A | Stilbene glucoside dimer compound and preparation method and application thereof | 中国食品药品检定研究院 | 2022-10-11 | — | — | CN | claimed |
| CN-108531465-B | Cyclic dipeptide synthetase and application thereof | 南京农业大学 | 2022-05-17 | — | — | CN | claimed |
| EP-3941930-A1 | CONTROL OF NITROGEN FIXATION IN RHIZOBIA THAT ASSOCIATE WITH CEREALS | Massachusetts Institute of Technology (US) | 2022-01-26 | — | — | EP | claimed |
| US-12635629-B2 | Canola hybrid 18GM0769N | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2026-05-26 | — | — | US | disclosed |
| US-12628762-B1 | Maize inbred 1PSMJ48 | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2026-05-19 | — | — | US | disclosed |
| WO-2026102217-A2 | INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2026-05-15 | — | — | WO | disclosed |
| US-20260132417-A1 | INSECTICIDAL PROTEINS COMPOSITIONS AND METHODS OF USE | GENECTIVE SA (US) | 2026-05-14 | — | — | US | disclosed |
| EP-4737471-A1 | METHODS FOR THE C-TERMINAL MODIFICATION OF (POLY)PEPTIDES | NUMAFERM GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| US-12616112-B2 | Canola inbred 4PWGT51R | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2026-05-05 | — | — | US | disclosed |
| US-12616111-B2 | Canola hybrid 18GM0788N | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2026-05-05 | — | — | US | disclosed |
| CN-114078378-A | Display device | 三星显示有限公司 | 2022-02-22 | — | — | CN | disclosed |
| US-20220052280-A1 | DISPLAY DEVICE AND METHOD FOR MANUFACTURING THE SAME | SAMSUNG DISPLAY CO., LTD. (KR) | 2022-02-17 | — | — | US | disclosed |
| EP-3954202-A1 | INSECTICIDAL PROTEINS FROM PLANTS AND METHODS FOR THEIR USE | Pioneer Hi-Bred International, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-114045232-A | Organic material rapid fermentation synergistic microbial inoculum and application thereof | 领先生物农业股份有限公司 | 2022-02-15 | — | — | CN | disclosed |
| US-11248204-B2 | Biologicals and their use in plants | DANISCO US INC | 2022-02-15 | — | — | US | disclosed |
| US-20220025411-A1 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE | GENOMATICA INC (US) | 2022-01-27 | — | — | US | disclosed |
| EP-3941930-A1 | CONTROL OF NITROGEN FIXATION IN RHIZOBIA THAT ASSOCIATE WITH CEREALS | Massachusetts Institute of Technology (US) | 2022-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260132417-A1 | INSECTICIDAL PROTEINS COMPOSITIONS AND METHODS OF USE | RNGTT, SRRT, CUTA | PDE5A 3129/4885KCNH2 4492/4885PDE6A 2356/4885 |
| US-12635629-B2 | Canola hybrid 18GM0769N | UGCG, DAGLA, HSP90AA1 | PDE5A 1012/4885KCNH2 4200/4885PDE6A 2302/4885 |
| US-12616112-B2 | Canola inbred 4PWGT51R | GET3, CYP4Z1, FAR1 | PDE5A 1806/4885KCNH2 4382/4885PDE6A 3370/4885 |
| US-12628762-B1 | Maize inbred 1PSMJ48 | MSL1, HSF1, TIMM44 | PDE5A 4567/4885KCNH2 3758/4885PDE6A 4712/4885 |
| US-12616111-B2 | Canola hybrid 18GM0788N | UGCG, GET3, PTAR1 | PDE5A 523/4885KCNH2 4417/4885PDE6A 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.