Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823148 | 1.00 | ELANE (0.65) | ELANEALDH1A1CA12CA9MAPT | |
| SCHEMBL11870038 | 0.86 | ELANE (0.61) | ELANEALDH1A1CA12CA9MAPT | |
| SCHEMBL11871329 | 0.86 | ELANE (0.70) | ELANEALDH1A1CA12CA9MAPT | |
| SCHEMBL11867108 | 0.83 | ELANE (0.58) | ELANEALDH1A1CA12CA9MAPT | |
| Ethylene SCHEMBL11863886 | 0.83 | ELANE (0.67) | ELANEALDH1A1CA12CA9MAPT | |
| SCHEMBL11509522 | 0.83 | ALDH1A1 (0.60) | ELANEALDH1A1CA12CA9MAPT | |
| SCHEMBL11509296 | 0.82 | ELANE (0.57) | ELANEALDH1A1CA12CA9MAPT | |
| Ethylene SCHEMBL11865796 | 0.80 | ELANE (0.56) | ELANEALDH1A1CA12CA9MAPT | |
| SCHEMBL12902033 | 0.80 | ELANE (0.56) | ELANEALDH1A1CA12CA9MAPT | |
| SCHEMBL2253697 | 0.79 | CA12 (0.58) | ELANEALDH1A1CA12CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118344372-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118255773-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-118255774-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2024-06-28 | — | — | CN | disclosed |
| EP-4077312-A1 | SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES | Janssen Pharmaceutica NV (BE) | 2022-10-26 | — | — | EP | disclosed |
| CN-114867721-A | Substituted straight-chain spiro derivatives | 詹森药业有限公司 | 2022-08-05 | — | — | CN | disclosed |