Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.55 |
| ▸ | JAK2 | O60674 | 14/20 | 0.55 |
| ▸ | JAK1 | P23458 | 14/20 | 0.55 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24615501 | 1.00 | TYK2 (0.55) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL29772793 | 0.89 | JAK2 (0.52) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615337 | 0.89 | JAK2 (0.52) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615619 | 0.87 | JAK1 (0.56) | TYK2JAK2JAK1JAK3KDR | |
| SCHEMBL24615480 | 0.86 | KIT (0.52) | TYK2JAK2JAK1KIT | |
| SCHEMBL24615509 | 0.85 | TYK2 (0.51) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615496 | 0.85 | JAK2 (0.56) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL22568679 | 0.85 | KIT (0.51) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL24615508 | 0.84 | KIT (0.44) | TYK2JAK2JAK1JAK3KIT | |
| SCHEMBL24615536 | 0.83 | JAK1 (0.48) | TYK2JAK2JAK1KITAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117098763-A | TYK2 inhibitors | 渤健马萨诸塞州股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| EP-4274832-A1 | TYK2 INHIBITORS | Biogen MA Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022150446-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2022-07-14 | — | — | WO | disclosed |