Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 20/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 16/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 16/20 | 1.00 |
| ▸ | NTRK3 | Q16288 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16763000 | 1.00 | CSF1R (1.00) | CSF1RNTRK1NTRK2NTRK3 | |
| SCHEMBL16785843 | 0.90 | CSF1R (0.82) | CSF1RNTRK1NTRK2NTRK3 | |
| Gz-389988 SCHEMBL16762937 | 0.88 | CSF1R (1.00) | CSF1RNTRK1NTRK2NTRK3 | |
| Gz-389988 SCHEMBL29774374 | 0.88 | CSF1R (1.00) | CSF1RNTRK1NTRK2NTRK3 | |
| Gz-389988 SCHEMBL29589607 | 0.88 | CSF1R (1.00) | CSF1RNTRK1NTRK2NTRK3 | |
| Gz-389988 SCHEMBL31167982 | 0.87 | CSF1R (0.98) | CSF1RNTRK1NTRK2NTRK3 | |
| Gz-389988 SCHEMBL17843975 | 0.87 | CSF1R (0.98) | CSF1RNTRK1NTRK2NTRK3 | |
| Gz-389988 SCHEMBL30387411 | 0.87 | CSF1R (0.98) | CSF1RNTRK1NTRK2NTRK3 | |
| SCHEMBL16762929 | 0.87 | CSF1R (1.00) | CSF1RNTRK1NTRK2NTRK3 | |
| SCHEMBL29774346 | 0.87 | CSF1R (1.00) | CSF1RNTRK1NTRK2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250288595-A1 | TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORP (US) | 2025-09-18 | — | — | US | disclosed |
| US-12318392-B2 | Tropomyosin-related kinase (trk) inhibitors | GENZYME CORPORATION (US) | 2025-06-03 | — | — | US | disclosed |
| US-20240189322-A1 | TROPOMYOSIN-RELATED KINASE (trk) INHIBITORS | GENZYME CORPORATION | 2024-06-13 | — | — | US | disclosed |
| US-11878024-B2 | Tropomyosin-related kinase (Trk) inhibitors | GENZYME CORPORATION (US) | 2024-01-23 | — | — | US | disclosed |
| US-20230080874-A1 | TROPOMYOSIN-RELATED KINASE (trk) INHIBITORS | GENZYME CORPORATION | 2023-03-16 | — | — | US | disclosed |
| US-11406644-B2 | Tropomyosin-related kinase (TRK) inhibitors | GENZYME CORPORATION (US) | 2022-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12318392-B2 | Tropomyosin-related kinase (trk) inhibitors | NTRK1, NGF, NTRK2 | CSF1R 4/4885NTRK1 1/4885NTRK2 3/4885 |
| US-11406644-B2 | Tropomyosin-related kinase (TRK) inhibitors | NTRK1, NGF, NTRK2 | CSF1R 4/4885NTRK1 1/4885NTRK2 3/4885 |
| US-20230080874-A1 | TROPOMYOSIN-RELATED KINASE (trk) INHIBITORS | NTRK1, NGF, NTRK2 | CSF1R 4/4885NTRK1 1/4885NTRK2 3/4885 |
| US-20240189322-A1 | TROPOMYOSIN-RELATED KINASE (trk) INHIBITORS | NTRK1, NGF, NTRK2 | CSF1R 4/4885NTRK1 1/4885NTRK2 3/4885 |
| US-11878024-B2 | Tropomyosin-related kinase (Trk) inhibitors | NTRK1, NGF, NTRK2 | CSF1R 4/4885NTRK1 1/4885NTRK2 3/4885 |
| US-20250288595-A1 | TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | NTRK1, NGF, NTRK2 | CSF1R 4/4885NTRK1 1/4885NTRK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.