NGF — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15683182	1.00	1/20
Lumiflavin (SCHEMBL193713)	0.76	1/20
Lumiflavin (SCHEMBL6365933)	0.74	1/20
Lumiflavin (SCHEMBL6373617)	0.72	1/20
SCHEMBL864918	0.69	1/20
SCHEMBL9022677	0.69	1/20
SCHEMBL10285873	0.66	1/20
SCHEMBL4748217	0.62	1/20
SCHEMBL13955810	0.61	1/20
SCHEMBL9635901	0.61	1/20
SCHEMBL5710753	0.60	1/20
SCHEMBL3476023	0.56	1/20
SCHEMBL864130	0.56	1/20
SCHEMBL864557	0.55	1/20
SCHEMBL6032312	0.55	1/20
SCHEMBL8330862	0.55	1/20
SCHEMBL863817	0.55	1/20
SCHEMBL864193	0.53	1/20
SCHEMBL11304043	0.53	1/20
SCHEMBL864619	0.53	1/20

Clinical trials — most relevant to NGF by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Impact of Electroacupuncture Combined With NGF on Clinical Effect and Functional Changes on Ischemic Stroke	PHASE4	UNKNOWN
Effect of Minocycline on Pain Caused by Nerve Damage	PHASE4	COMPLETED
The Effect of Oral DLBS1033 in Patients With Diabetic Polyneuropathy	PHASE2/PHASE3	NOT_YET_RECRUITING
Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial	PHASE3	COMPLETED
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)	PHASE2	ACTIVE_NOT_RECRUITING
Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's Disease	PHASE2	COMPLETED
Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders	PHASE1/PHASE2	COMPLETED
Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome	PHASE1/PHASE2	COMPLETED
Effects of Intranasal Nerve Growth Factor for Traumatic Brain Injury	PHASE2	COMPLETED
tDCS Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease	PHASE2	UNKNOWN
Cilostazol in Parkinson's Disease	PHASE2	NOT_YET_RECRUITING
The Phase I Study of Recombinant Human Nerve Growth Factor Injection	PHASE1	UNKNOWN
A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment	PHASE1	RECRUITING
a Safety and Tolerability Study of EP-9001A in Healthy Volunteers	PHASE1	UNKNOWN
Yogic Breathing Changes Salivary Components	nan	COMPLETED
Management of Retinitis Pigmentosa Via Electromagnetic Stimulation and Platelet Rich Plasma	nan	COMPLETED
Ultrasound Guided Placental Growth Factor Vs Platelet Rich Plasma Injection in Peripheral Nerve Injury: an Interventional Study	nan	NOT_YET_RECRUITING
Determination of Nerve Growth Factor (NGF) Expression in Pediatric Patients With Severe Burns: a Pilot Study	nan	COMPLETED
Study of the Effect of Antidepressant Drugs on Neurotrophic Factors in Patients With Depression	nan	COMPLETED
Association of Urine BDNF and NGF With Lower Urinary System Parameters	nan	RECRUITING
Regular Exercise Improves Physical Capacity and Promotes Neurotrophins in Patients With Multiple Sclerosis	nan	COMPLETED
Cord Blood Serum in the Treatment of Neuro-Degenerative Ophthalmic Diseases. 1-Glaucoma	nan	COMPLETED
IGF and Other Neurotrophic Factors in Patients With Dementia	nan	COMPLETED
Feasibility of Pain Informed Movement for Knee OA	nan	COMPLETED
Urinary Neurotrophin Levels as Potential Biomarkers for Overactive Bladder: A Case-Control Study	nan	ENROLLING_BY_INVITATION
Biomarkers in Blood and Tissue Samples From Patients With Newly Diagnosed Neuroblastoma	nan	COMPLETED
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting	nan	UNKNOWN
Vitamin D, Nerve Growth Factor and Nerve Conduction Studies in Adult Male Type 2 Diabetic Neuropathy Patients	nan	NOT_YET_RECRUITING
The Role of Urinary ATP in the Diagnosis, Treatment, and Follow-up of Children With Overactive Bladder	nan	COMPLETED
The Relationship Between Chronic OA Pain and Cognition Deficits in OA Patients.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NGF binder may also engage these)

Protein	Name	Similarity
Q9N2F0	—	1.000	Q9N2F0 →
Q9N2F1	—	1.000	Q9N2F1 →
Q5ISB0	—	1.000	Q5ISB0 →
Q9N2E9	—	1.000	Q9N2E9 →
P13600	—	1.000	P13600 →
P20675	—	1.000	P20675 →
P25427	—	1.000	P25427 →
P01139	—	1.000	P01139 →
Q29074	—	1.000	Q29074 →
P19093	—	1.000	P19093 →
Q3HXY9	—	1.000	Q3HXY9 →
P05200	—	1.000	P05200 →
Q3HXY8	—	1.000	Q3HXY8 →
Q3HXX8	—	1.000	Q3HXX8 →
Q9TST2	—	1.000	Q9TST2 →
Q06AV0	—	1.000	Q06AV0 →
Q5YF90	—	1.000	Q5YF90 →
Q3HXY4	—	1.000	Q3HXY4 →
P20783	—	1.000	P20783 →
A6MFL5	—	1.000	A6MFL5 →
Q9DEZ9	—	1.000	Q9DEZ9 →
Q3HXZ0	—	1.000	Q3HXZ0 →
Q3HXZ1	—	0.999	Q3HXZ1 →
A6MFL7	—	0.999	A6MFL7 →
Q3HXY3	—	0.999	Q3HXY3 →
Q3I5F4	—	0.999	Q3I5F4 →
Q3HXX6	—	0.999	Q3HXX6 →
P18280	—	0.999	P18280 →
Q3HXY6	—	0.999	Q3HXY6 →
O70183	—	0.999	O70183 →