Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | DTYMK | P23919 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31338514 | 1.00 | MAPT (0.60) | MAPTDTYMKNPSR1PTGS2ALDH1A1 | |
| SCHEMBL1371283 | 0.87 | MAPT (0.57) | MAPTDTYMKNPSR1PTGS2ALDH1A1 | |
| SCHEMBL341056 | 0.87 | MAPT (0.60) | MAPTDTYMKNPSR1PTGS2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1890620 | 0.85 | MAPT (0.56) | MAPTDTYMKNPSR1PTGS2ALDH1A1 | |
| SCHEMBL27248589 | 0.85 | MAPT (0.58) | MAPTDTYMKNPSR1PTGS2ALDH1A1 | |
| SCHEMBL7497984 | 0.84 | DTYMK (0.51) | MAPTDTYMKNPSR1PTGS2ALDH1A1 | |
| SCHEMBL25410942 | 0.83 | RAB9A (0.53) | MAPTNPSR1PTGS2ALDH1A1HCAR3 | |
| SCHEMBL31366512 | 0.83 | RAB9A (0.53) | MAPTNPSR1PTGS2ALDH1A1HCAR3 | |
| SCHEMBL2061821 | 0.83 | MAPT (0.55) | MAPTNPSR1PTGS2ALDH1A1HCAR3 | |
| SCHEMBL6081366 | 0.83 | HCAR3 (0.54) | MAPTDTYMKALDH1A1HCAR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283151-B1 | DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET | F2G LTD (GB) | 2017-03-08 | — | — | EP | disclosed |
| CN-103784458-B | Phenylalamine derivatives | AJINOMOTO K. K. (JP) | 2015-10-14 | — | — | CN | disclosed |
| EP-1595870-B1 | PROCESS FOR PRODUCING PHENYLALANINE DERIVATIVE HAVING QUINAZOLINEDIONE SKELETON AND INTERMEDIATE FOR THE SAME | AJINOMOTO KK (JP) | 2015-09-23 | — | — | EP | disclosed |
| EP-1700850-B1 | Phenylalanine derivative | AJINOMOTO KK (JP) | 2015-07-15 | — | — | EP | disclosed |
| US-9034887-B2 | Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof | F2G LIMITED (GB) | 2015-05-19 | — | — | US | disclosed |
| CN-1917881-B | Novel phenylalanine derivatives | AJINOMOTO KK | 2014-11-26 | — | — | CN | disclosed |
| EP-2803667-A1 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2014-11-19 | — | — | EP | disclosed |
| CN-103784458-A | Novel phenylalanine derivatives | AJINOMOTO KK | 2014-05-14 | — | — | CN | disclosed |
| CN-101589028-B | Process for production of phenylalanine derivatives having quinazolinedione skeletons and intermediates for the production | AJINOMOTO KK | 2014-02-19 | — | — | CN | disclosed |
| US-8546610-B2 | Method for preparing phenylalanine derivatives having quinazoline-dione skeleton and intermediates for use in the preparation of the derivatives | AJINOMOTO CO., INC. (JP) | 2013-10-01 | — | — | US | disclosed |
| WO-2005009969-A1 | AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI-AVENTIS (FR) | 2005-02-03 | — | — | WO | disclosed |
| US-5872115-A | COMPOUNDS FOR TREATMENT OF HYPERCHOLESTEROLEMIA, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISEASE OR ATHEROSCLEROSIS | GRELAN PHARMACEUTICAL CO. LTD. (JP) | 1999-02-16 | — | — | US | disclosed |
| WO-1997020822-A1 | QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |
| EP-0742208-A1 | 2-Ureido-benzamide derivatives | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0280187-B1 | HAIR DYEING COMPOSITIONS WITH DIRECT-DYEING NITRO-DIPHENYL AMINE DERIVATIVES | Henkel Kommanditgesellschaft auf Aktien (DE) | 1992-01-02 | — | — | EP | disclosed |
| US-4859206-A | Hair dye preparations containing nitrodiphenylamine derivative | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1989-08-22 | — | — | US | disclosed |
| EP-0280187-A1 | Hair dyeing compositions with direct-dyeing nitro-diphenyl amine derivatives | Henkel Kommanditgesellschaft auf Aktien (DE) | 1988-08-31 | — | — | EP | disclosed |
| US-4455311-A | Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system | HOFFMANN-LA ROCHE INC. (US) | 1984-06-19 | — | — | US | disclosed |
| EP-0073060-A1 | Imidazoquinazoline derivatives, their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-03-02 | — | — | EP | disclosed |
| US-4011323-A | ANTIOBESITY AND ANTIDIABETIC | SANDOZ, INC. (US) | 1977-03-08 | — | — | US | disclosed |