Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20472469 | 1.00 | CHRNA7 (0.76) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL13451876 | 0.90 | CHRNA7 (0.64) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL3681047 | 0.89 | CHRNA7 (0.67) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL13613542 | 0.89 | KDR (0.69) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL3680621 | 0.88 | CHRNA7 (0.62) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL5594738 | 0.88 | CHRNA7 (0.66) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL3680987 | 0.88 | CHRNA7 (0.62) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL9835452 | 0.88 | CHRNA7 (0.61) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL27322095 | 0.88 | CHRNA7 (0.61) | CHRNA7TP53GAAMAPTMEN1 | |
| SCHEMBL1013241 | 0.88 | ALDH1A1 (0.63) | CHRNA7TP53GAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291571-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022174035-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2022-08-18 | — | — | WO | disclosed |