Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14912399 | 0.78 | MAP4K4 (0.36) | KDM4EALDH1A1TSHRMAPTMAPK1 | |
| SCHEMBL14912161 | 0.75 | EHMT2 (0.34) | KDM4EALDH1A1MAPT | |
| SCHEMBL14915008 | 0.74 | DRD2 (0.35) | — | |
| SCHEMBL1392881 | 0.72 | LRRK2 (0.38) | MAPT | |
| SCHEMBL29777622 | 0.71 | GRM5 (0.37) | SMN1; SMN2KEAP1KDM4EALDH1A1TSHR | |
| SCHEMBL21964594 | 0.69 | POLB (0.40) | SMN1; SMN2KEAP1SIGMAR1MAPTPOLB | |
| SCHEMBL16524047 | 0.66 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL11856358 | 0.65 | KDM4E (0.70) | SMN1; SMN2KEAP1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL2822228 | 0.65 | KDM5A (0.49) | SMN1; SMN2KEAP1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL522026 | 0.65 | NR5A2 (0.45) | SMN1; SMN2KEAP1ALDH1A1SIGMAR1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108948019-B | Focal adhesion kinase inhibitors and uses thereof | 广东东阳光药业有限公司 | 2022-07-08 | — | — | CN | disclosed |