Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 8/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297511 | 1.00 | DDB1 (0.41) | DDB1CRBNFPR2SCN9APSEN1 | |
| SCHEMBL31748160 | 0.89 | PSEN1 (0.42) | DDB1CRBNFPR2PSEN1PSEN2 | |
| SCHEMBL15632987 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2SCN9A | |
| SCHEMBL4789557 | 0.83 | SLC6A4 (0.44) | DDB1CRBNFPR2PSEN1PSEN2 | |
| SCHEMBL15632988 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2SCN9A | |
| SCHEMBL20613502 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2SCN9A | |
| SCHEMBL16148496 | 0.82 | DDB1 (0.60) | DDB1CRBNROCK2 | |
| SCHEMBL16465787 | 0.80 | DDB1 (0.54) | DDB1CRBNMAOAMAOB | |
| SCHEMBL15633784 | 0.80 | DDB1 (0.54) | DDB1CRBNMAOAMAOB | |
| SCHEMBL15633358 | 0.80 | MCHR1 (0.40) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114716370-A | Pyridine-containing polycyclic derivative inhibitor, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-07-08 | — | — | CN | disclosed |