Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779407 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2PSEN1PSEN2 | |
| SCHEMBL15632988 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2 | |
| SCHEMBL20613502 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2 | |
| SCHEMBL15632987 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2 | |
| SCHEMBL19297511 | 0.83 | DDB1 (0.41) | DDB1CRBNFPR2PSEN1PSEN2 | |
| SCHEMBL16148496 | 0.82 | DDB1 (0.60) | SLC6A4SLC6A2SLC6A3DDB1CRBN | |
| SCHEMBL16465787 | 0.80 | DDB1 (0.54) | DDB1CRBN | |
| SCHEMBL15633784 | 0.80 | DDB1 (0.54) | DDB1CRBN | |
| SCHEMBL23633021 | 0.79 | SCN9A (0.49) | DDB1CRBNFPR2 | |
| SCHEMBL15633085 | 0.79 | FPR2 (0.42) | SLC6A4SLC6A2SLC6A3DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150231-A1 | NEW HETEROCYCLIC COMPOUNDS FOR TREATMENT OF RESPIRATORY, AIRWAY OR INFLAMMATORY DISORDERS | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | claimed |
| WO-2008150231-A1 | NEW HETEROCYCLIC COMPOUNDS FOR TREATMENT OF RESPIRATORY, AIRWAY OR INFLAMMATORY DISORDERS | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008150231-A1 | NEW HETEROCYCLIC COMPOUNDS FOR TREATMENT OF RESPIRATORY, AIRWAY OR INFLAMMATORY DISORDERS | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |