Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.46 |
| ▸ | CDK4 | P11802 | 6/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 6/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29287418 | 1.00 | AURKA (0.46) | AURKACDK4CDK1KDRINSR | |
| SCHEMBL8513398 | 0.77 | AURKA (0.46) | AURKACDK4CDK1KDRINSR | |
| SCHEMBL4202568 | 0.77 | CDK4 (0.47) | AURKACDK4CDK1KDRINSR | |
| SCHEMBL29990953 | 0.76 | CCND1 (0.56) | CDK4CDK1CDK2 | |
| SCHEMBL574660 | 0.76 | CCND1 (0.56) | CDK4CDK1CDK2 | |
| SCHEMBL5263603 | 0.75 | CCND1 (0.57) | CDK4CDK1CDK2 | |
| SCHEMBL4828470 | 0.75 | CCND1 (0.57) | CDK4CDK1CDK2 | |
| SCHEMBL29287417 | 0.74 | TTK (0.46) | AURKACDK4CDK1KDRINSR | |
| SCHEMBL586028 | 0.74 | AURKA (0.46) | AURKACDK4CDK1KDRINSR | |
| SCHEMBL1356072 | 0.73 | AURKA (0.46) | AURKACDK1AURKBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114751909-A | Preparation method of Ribociclib intermediate | 杭州福斯特药业有限公司 | 2022-07-15 | — | — | CN | disclosed |