Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.54 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555005 | 1.00 | KDM4E (0.59) | KDM4ELMNAHTTGPR35DHODH | |
| SCHEMBL19554566 | 0.87 | KDM4E (0.47) | KDM4ELMNAHTTGPR35MEN1 | |
| SCHEMBL19578217 | 0.84 | CYP19A1 (0.51) | KDM4ELMNAHTTGPR35MEN1 | |
| SCHEMBL19554535 | 0.82 | KDM4E (0.42) | KDM4ELMNAHTTDHODHEIF4E | |
| SCHEMBL19578230 | 0.79 | RXFP1 (0.46) | KDM4ELMNAHTTGPR35MEN1 | |
| SCHEMBL19578216 | 0.79 | RXFP1 (0.46) | KDM4ELMNAHTTGPR35MEN1 | |
| SCHEMBL29779685 | 0.78 | KDM4E (0.53) | KDM4ELMNAHTTGPR35DHODH | |
| SCHEMBL19554482 | 0.78 | KDM4E (0.53) | KDM4ELMNAHTTGPR35DHODH | |
| SCHEMBL19555149 | 0.77 | MAPT (0.43) | KDM4ELMNAHTTGPR35MEN1 | |
| SCHEMBL19554455 | 0.75 | ALDH1A1 (0.42) | KDM4EGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311902-B | Substituted imidazo [1,2-b ] pyridazines, imidazo [1,5-b ] pyridazines, related compounds, and uses thereof | BIAL研发投资股份有限公司 | 2022-07-15 | — | — | CN | disclosed |