Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.43 |
| ▸ | SUV39H1 | O43463 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 8/20 | 0.43 |
| ▸ | BCHE | P06276 | 5/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.39 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chimonanthine SCHEMBL29779948 | 1.00 | TACR1 (0.43) | TACR1EHMT2SUV39H1ACHEBCHE | |
| Calycanthine SCHEMBL893195 | 1.00 | TACR1 (0.43) | TACR1EHMT2SUV39H1ACHEBCHE | |
| Calycanthine SCHEMBL29878816 | 1.00 | TACR1 (0.43) | TACR1EHMT2SUV39H1ACHEBCHE | |
| Chimonanthine SCHEMBL20927442 | 1.00 | TACR1 (0.43) | TACR1EHMT2SUV39H1ACHEBCHE | |
| Chimonanthine SCHEMBL29515267 | 1.00 | TACR1 (0.43) | TACR1EHMT2SUV39H1ACHEBCHE | |
| SCHEMBL30555832 | 0.87 | TACR1 (0.39) | TACR1EHMT2SUV39H1ACHEBCHE | |
| SCHEMBL20927487 | 0.85 | TACR1 (0.36) | TACR1EHMT2SUV39H1ACHEBCHE | |
| SCHEMBL20927482 | 0.85 | TACR1 (0.36) | TACR1EHMT2SUV39H1ACHEBCHE | |
| SCHEMBL19655969 | 0.85 | TACR1 (0.36) | TACR1EHMT2SUV39H1ACHEBCHE | |
| SCHEMBL19657100 | 0.85 | TACR1 (0.36) | TACR1EHMT2SUV39H1ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030888-B2 | Himastatin derivatives, and processes of preparation thereof, and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2024-07-09 | — | — | US | disclosed |
| US-20220289750-A1 | HIMASTATIN DERIVATIVES, AND PROCESSES OF PREPARATION THEREOF, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2022-09-15 | — | — | US | disclosed |
| WO-2022182415-A1 | HIMASTATIN DERIVATIVES, AND PROCESSES OF PREPARATION THEREOF, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2022-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030888-B2 | Himastatin derivatives, and processes of preparation thereof, and uses thereof | PCSK9, HMGCR, PCSK7 | TACR1 3035/4885EHMT2 1875/4885SUV39H1 1693/4885 |
| US-20220289750-A1 | HIMASTATIN DERIVATIVES, AND PROCESSES OF PREPARATION THEREOF, AND USES THEREOF | PCSK9, HMGCR, PCSK7 | TACR1 3035/4885EHMT2 1875/4885SUV39H1 1693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.