Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 10/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461094 | 1.00 | IDH1 (0.37) | IDH1ACP1AURKATAS2R14IDH2 | |
| SCHEMBL23461602 | 0.82 | EPAS1 (0.42) | — | |
| SCHEMBL29780196 | 0.82 | EPAS1 (0.42) | — | |
| SCHEMBL29780239 | 0.80 | EPAS1 (0.41) | — | |
| SCHEMBL23461066 | 0.80 | EPAS1 (0.41) | — | |
| SCHEMBL23462206 | 0.74 | IDO1 (0.44) | IDH1GRM5CSNK2A1CYP1A2METAP2 | |
| SCHEMBL29780223 | 0.74 | IDO1 (0.44) | IDH1GRM5CSNK2A1CYP1A2METAP2 | |
| SCHEMBL23478145 | 0.73 | METAP2 (0.38) | IDH1GRM5CSNK2A1CYP1A2METAP2 | |
| SCHEMBL29780227 | 0.73 | METAP2 (0.38) | IDH1GRM5CSNK2A1CYP1A2METAP2 | |
| SCHEMBL23478125 | 0.69 | EPAS1 (0.39) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114760994-A | Inhibitors of HIF-2 alpha | 艾库斯生物科学有限公司 | 2022-07-15 | — | — | CN | disclosed |