Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | JAK3 | P52333 | 7/20 | 0.45 |
| ▸ | JAK1 | P23458 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052236 | 0.80 | JAK2 (0.46) | RETKDRJAK2JAK3JAK1 | |
| SCHEMBL29780904 | 0.80 | JAK2 (0.46) | RETKDRJAK2JAK3JAK1 | |
| SCHEMBL20533043 | 0.80 | CYP1A2 (0.61) | RETKDRCYP1A2MAPK1KDM4E | |
| SCHEMBL15826969 | 0.80 | PIK3CD (0.51) | RETKDRJAK2JAK3JAK1 | |
| SCHEMBL29052107 | 0.79 | JAK2 (0.47) | JAK2JAK3JAK1ADK | |
| SCHEMBL29780975 | 0.79 | JAK2 (0.47) | JAK2JAK3JAK1ADK | |
| SCHEMBL19732713 | 0.77 | RET (0.60) | RETKDRCYP1A2MAPK1KDM4E | |
| SCHEMBL29052149 | 0.77 | ADORA2A (0.49) | RETKDRJAK2JAK3JAK1 | |
| SCHEMBL19476278 | 0.77 | ADORA2A (0.49) | RETKDRJAK2JAK3JAK1 | |
| SCHEMBL29781034 | 0.77 | ADORA2A (0.49) | RETKDRJAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |