Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.46 |
| ▸ | JAK3 | P52333 | 7/20 | 0.46 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | ADK | P55263 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | PRKDC | P78527 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052236 | 1.00 | JAK2 (0.46) | JAK2JAK3JAK1ADKSRC | |
| SCHEMBL29781034 | 0.84 | ADORA2A (0.49) | JAK2JAK3JAK1ADKSRC | |
| SCHEMBL19476278 | 0.84 | ADORA2A (0.49) | JAK2JAK3JAK1ADKSRC | |
| SCHEMBL29052149 | 0.84 | ADORA2A (0.49) | JAK2JAK3JAK1ADKSRC | |
| SCHEMBL21851263 | 0.82 | ADORA2A (0.51) | JAK2JAK3JAK1ADKSRC | |
| SCHEMBL15826969 | 0.81 | PIK3CD (0.51) | JAK2JAK3JAK1ADKSRC | |
| SCHEMBL29052107 | 0.80 | JAK2 (0.47) | JAK2JAK3JAK1ADKADORA2A | |
| SCHEMBL29780975 | 0.80 | JAK2 (0.47) | JAK2JAK3JAK1ADKADORA2A | |
| SCHEMBL29780853 | 0.80 | RET (0.47) | JAK2JAK3JAK1ADKDYRK1A | |
| SCHEMBL29052129 | 0.80 | JAK2 (0.45) | JAK2JAK3JAK1ADKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583287-A | Pyridazinone heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |